Spatial Distribution of Cerebral White Matter Lesions Predicts Progression to Mild Cognitive Impairment and Dementia
Identifieur interne : 004474 ( Main/Exploration ); précédent : 004473; suivant : 004475Spatial Distribution of Cerebral White Matter Lesions Predicts Progression to Mild Cognitive Impairment and Dementia
Auteurs : Marion Mortamais [France] ; Christelle Reynes [France] ; Adam M. Brickman [États-Unis] ; Frank A. Provenzano [États-Unis] ; Jordan Muraskin [États-Unis] ; Florence Portet [France] ; Claudine Berr [France] ; Jacques Touchon [France] ; Alain Bonafé [France] ; Emmanuelle Le Bars [France] ; Jerome J. Maller [Australie] ; Chantal Meslin [Australie] ; Robert Sabatier [France] ; Karen Ritchie [France, Royaume-Uni] ; Sylvaine Artero [France]Source :
- PLoS ONE [ 1932-6203 ] ; 2013.
Abstract
White matter lesions (WML) increase the risk of dementia. The relevance of WML location is less clear. We sought to determine whether a particular WML profile, based on the density and location of lesions, could be associated with an increased risk of mild cognitive impairment (MCI) or dementia over the following 7 years.
In 426 healthy subjects from a cohort of community-dwelling people aged 65 years and over (ESPRIT Project), standardized cognitive and neurological evaluations were repeated after 2, 4 and 7 years. Patterns of WML were computed with a supervised data mining approach (decision trees) using the regional WML volumes (frontal, parietal, temporal, and occipital regions) and the total WML volume estimated at baseline. Cox proportional hazard models were then constructed to study the association between WML patterns and risk of MCI/dementia.
Total WML volume and percentage of WML in the temporal region proved to be the best predictors of progression to MCI and dementia. Specifically, severe total WML load with a high proportion of lesions in the temporal region was significantly associated with the risk of developing MCI or dementia.
Above a certain threshold of damage, a pattern of WML clustering in the temporal region identifies individuals at increased risk of MCI or dementia. As this WML pattern is observed before the onset of clinical symptoms, it may facilitate the detection of patients at risk of MCI/dementia.
Url:
DOI: 10.1371/journal.pone.0056972
PubMed: 23457645
PubMed Central: 3572965
Affiliations:
- Australie, France, Royaume-Uni, États-Unis
- Angleterre, Grand Londres, Languedoc-Roussillon, Occitanie (région administrative), Victoria (État), État de New York
- Londres, Melbourne, Montpellier, New York, Nîmes
- Université Columbia
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Progression to Mild Cognitive Impairment and Dementia</title><author><name sortKey="Mortamais, Marion" sort="Mortamais, Marion" uniqKey="Mortamais M" first="Marion" last="Mortamais">Marion Mortamais</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Inserm, U1061, La Colombière Hospital, Montpellier, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U1061, La Colombière Hospital, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>University of Montpellier 1, Montpellier, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University of Montpellier 1, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Reynes, Christelle" sort="Reynes, Christelle" uniqKey="Reynes C" first="Christelle" last="Reynes">Christelle Reynes</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>University of Montpellier 1, Montpellier, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University of Montpellier 1, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>EA 2415, Faculté de Pharmacie, Montpellier, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>EA 2415, Faculté de Pharmacie, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Brickman, Adam M" sort="Brickman, Adam M" uniqKey="Brickman A" first="Adam M." last="Brickman">Adam M. Brickman</name><affiliation wicri:level="4"><nlm:aff id="aff4"><addr-line>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, College of Physicians and Surgeons, New York, New York, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, College of Physicians and Surgeons, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Provenzano, Frank A" sort="Provenzano, Frank A" uniqKey="Provenzano F" first="Frank A." last="Provenzano">Frank A. Provenzano</name><affiliation wicri:level="4"><nlm:aff id="aff4"><addr-line>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, College of Physicians and Surgeons, New York, New York, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, College of Physicians and Surgeons, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Muraskin, Jordan" sort="Muraskin, Jordan" uniqKey="Muraskin J" first="Jordan" last="Muraskin">Jordan Muraskin</name><affiliation wicri:level="4"><nlm:aff id="aff4"><addr-line>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, College of Physicians and Surgeons, New York, New York, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, College of Physicians and Surgeons, New York, New York</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">New York</settlement></placeName><orgName type="university">Université Columbia</orgName></affiliation></author><author><name sortKey="Portet, Florence" sort="Portet, Florence" uniqKey="Portet F" first="Florence" last="Portet">Florence Portet</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Inserm, U1061, La Colombière Hospital, Montpellier, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U1061, La Colombière Hospital, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff5"><addr-line>Unité Transversale des Troubles Neurologiques du Sujet Âgé, CHU Caremeau, Centre Ruffi, Pôle de Gériatrie, CHU Nîmes, Nîmes, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité Transversale des Troubles Neurologiques du Sujet Âgé, CHU Caremeau, Centre Ruffi, Pôle de Gériatrie, CHU Nîmes, Nîmes</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Nîmes</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff6"><addr-line>Montpellier University Hospital, University Department of Adult Psychiatry, La Colombière Hospital, CHU de Montpellier, Montpellier, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Montpellier University Hospital, University Department of Adult Psychiatry, La Colombière Hospital, CHU de Montpellier, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Berr, Claudine" sort="Berr, Claudine" uniqKey="Berr C" first="Claudine" last="Berr">Claudine Berr</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Inserm, U1061, La Colombière Hospital, Montpellier, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U1061, La Colombière Hospital, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>University of Montpellier 1, Montpellier, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University of Montpellier 1, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Touchon, Jacques" sort="Touchon, Jacques" uniqKey="Touchon J" first="Jacques" last="Touchon">Jacques Touchon</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Inserm, U1061, La Colombière Hospital, Montpellier, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U1061, La Colombière Hospital, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>University of Montpellier 1, Montpellier, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University of Montpellier 1, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Bonafe, Alain" sort="Bonafe, Alain" uniqKey="Bonafe A" first="Alain" last="Bonafé">Alain Bonafé</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>University of Montpellier 1, Montpellier, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University of Montpellier 1, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff7"><addr-line>CHRU Montpellier, Montpellier, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CHRU Montpellier, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Le Bars, Emmanuelle" sort="Le Bars, Emmanuelle" uniqKey="Le Bars E" first="Emmanuelle" last="Le Bars">Emmanuelle Le Bars</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>University of Montpellier 1, Montpellier, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University of Montpellier 1, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff7"><addr-line>CHRU Montpellier, Montpellier, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CHRU Montpellier, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Maller, Jerome J" sort="Maller, Jerome J" uniqKey="Maller J" first="Jerome J." last="Maller">Jerome J. Maller</name><affiliation wicri:level="3"><nlm:aff id="aff8"><addr-line>Monash Alfred Psychiatry Research Centre, The Alfred and Monash University Central Clinical School, Melbourne, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Monash Alfred Psychiatry Research Centre, The Alfred and Monash University Central Clinical School, Melbourne</wicri:regionArea><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Meslin, Chantal" sort="Meslin, Chantal" uniqKey="Meslin C" first="Chantal" last="Meslin">Chantal Meslin</name><affiliation wicri:level="1"><nlm:aff id="aff9"><addr-line>Centre for Mental Health Research, Australian National University, Canberra, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Mental Health Research, Australian National University, Canberra</wicri:regionArea><wicri:noRegion>Canberra</wicri:noRegion></affiliation></author><author><name sortKey="Sabatier, Robert" sort="Sabatier, Robert" uniqKey="Sabatier R" first="Robert" last="Sabatier">Robert Sabatier</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>University of Montpellier 1, Montpellier, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University of Montpellier 1, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>EA 2415, Faculté de Pharmacie, Montpellier, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>EA 2415, Faculté de Pharmacie, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Inserm, U1061, La Colombière Hospital, Montpellier, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U1061, La Colombière Hospital, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>University of Montpellier 1, Montpellier, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University of Montpellier 1, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff10"><addr-line>Faculty of Medicine, Imperial College, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Faculty of Medicine, Imperial College, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Artero, Sylvaine" sort="Artero, Sylvaine" uniqKey="Artero S" first="Sylvaine" last="Artero">Sylvaine Artero</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Inserm, U1061, La Colombière Hospital, Montpellier, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Inserm, U1061, La Colombière Hospital, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>University of Montpellier 1, Montpellier, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>University of Montpellier 1, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Context</title><p>White matter lesions (WML) increase the risk of dementia. The relevance of WML location is less clear. We sought to determine whether a particular WML profile, based on the density and location of lesions, could be associated with an increased risk of mild cognitive impairment (MCI) or dementia over the following 7 years.</p></sec><sec><title>Methods</title><p>In 426 healthy subjects from a cohort of community-dwelling people aged 65 years and over (ESPRIT Project), standardized cognitive and neurological evaluations were repeated after 2, 4 and 7 years. Patterns of WML were computed with a supervised data mining approach (decision trees) using the regional WML volumes (frontal, parietal, temporal, and occipital regions) and the total WML volume estimated at baseline. Cox proportional hazard models were then constructed to study the association between WML patterns and risk of MCI/dementia.</p></sec><sec><title>Results</title><p>Total WML volume and percentage of WML in the temporal region proved to be the best predictors of progression to MCI and dementia. Specifically, severe total WML load with a high proportion of lesions in the temporal region was significantly associated with the risk of developing MCI or dementia.</p></sec><sec><title>Conclusions</title><p>Above a certain threshold of damage, a pattern of WML clustering in the temporal region identifies individuals at increased risk of MCI or dementia. 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Kennie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dubois, B" uniqKey="Dubois B">B Dubois</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Radloff, Ls" uniqKey="Radloff L">LS Radloff</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Lamarca, R" uniqKey="Lamarca R">R Lamarca</name></author><author><name sortKey="Alonso, J" uniqKey="Alonso J">J Alonso</name></author><author><name sortKey="Gomez, G" uniqKey="Gomez G">G Gomez</name></author><author><name sortKey="Munoz, A" uniqKey="Munoz A">A Munoz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Braak, H" uniqKey="Braak H">H Braak</name></author><author><name sortKey="Braak, E" uniqKey="Braak E">E Braak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bozzali, M" uniqKey="Bozzali M">M Bozzali</name></author><author><name sortKey="Falini, 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Yonezawa</name></author><author><name sortKey="Takahashi, J" uniqKey="Takahashi J">J Takahashi</name></author><author><name sortKey="Kudo, M" uniqKey="Kudo M">M Kudo</name></author><author><name sortKey="Inoue, T" uniqKey="Inoue T">T Inoue</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xie, S" uniqKey="Xie S">S Xie</name></author><author><name sortKey="Xiao, Jx" uniqKey="Xiao J">JX Xiao</name></author><author><name sortKey="Gong, Gl" uniqKey="Gong G">GL Gong</name></author><author><name sortKey="Zang, Yf" uniqKey="Zang Y">YF Zang</name></author><author><name sortKey="Wang, Yh" uniqKey="Wang Y">YH Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Herrmann, Ll" uniqKey="Herrmann L">LL Herrmann</name></author><author><name sortKey="Le Masurier, M" uniqKey="Le Masurier M">M Le Masurier</name></author><author><name sortKey="Ebmeier, Kp" uniqKey="Ebmeier K">KP Ebmeier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferri, Cp" uniqKey="Ferri C">CP Ferri</name></author><author><name sortKey="Prince, M" uniqKey="Prince M">M Prince</name></author><author><name sortKey="Brayne, C" uniqKey="Brayne C">C Brayne</name></author><author><name sortKey="Brodaty, H" uniqKey="Brodaty H">H Brodaty</name></author><author><name sortKey="Fratiglioni, L" uniqKey="Fratiglioni L">L Fratiglioni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Decarli, C" uniqKey="Decarli C">C DeCarli</name></author><author><name sortKey="Fletcher, E" uniqKey="Fletcher E">E Fletcher</name></author><author><name sortKey="Ramey, V" uniqKey="Ramey V">V Ramey</name></author><author><name sortKey="Harvey, D" uniqKey="Harvey D">D Harvey</name></author><author><name sortKey="Jagust, Wj" uniqKey="Jagust W">WJ Jagust</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Languedoc-Roussillon</li><li>Occitanie (région administrative)</li><li>Victoria (État)</li><li>État de New York</li></region><settlement><li>Londres</li><li>Melbourne</li><li>Montpellier</li><li>New York</li><li>Nîmes</li></settlement><orgName><li>Université Columbia</li></orgName></list><tree><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Mortamais, Marion" sort="Mortamais, Marion" uniqKey="Mortamais M" first="Marion" last="Mortamais">Marion Mortamais</name></region><name sortKey="Artero, Sylvaine" sort="Artero, Sylvaine" uniqKey="Artero S" first="Sylvaine" last="Artero">Sylvaine Artero</name><name sortKey="Artero, Sylvaine" sort="Artero, Sylvaine" uniqKey="Artero S" first="Sylvaine" last="Artero">Sylvaine Artero</name><name sortKey="Berr, Claudine" sort="Berr, Claudine" uniqKey="Berr C" first="Claudine" last="Berr">Claudine Berr</name><name sortKey="Berr, Claudine" sort="Berr, Claudine" uniqKey="Berr C" first="Claudine" last="Berr">Claudine Berr</name><name sortKey="Bonafe, Alain" sort="Bonafe, Alain" uniqKey="Bonafe A" first="Alain" last="Bonafé">Alain Bonafé</name><name sortKey="Bonafe, Alain" sort="Bonafe, Alain" uniqKey="Bonafe A" first="Alain" last="Bonafé">Alain Bonafé</name><name sortKey="Le Bars, Emmanuelle" sort="Le Bars, Emmanuelle" uniqKey="Le Bars E" first="Emmanuelle" last="Le Bars">Emmanuelle Le Bars</name><name sortKey="Le Bars, Emmanuelle" sort="Le Bars, Emmanuelle" uniqKey="Le Bars E" first="Emmanuelle" last="Le Bars">Emmanuelle Le Bars</name><name sortKey="Mortamais, Marion" sort="Mortamais, Marion" uniqKey="Mortamais M" first="Marion" last="Mortamais">Marion Mortamais</name><name sortKey="Portet, Florence" sort="Portet, Florence" uniqKey="Portet F" first="Florence" last="Portet">Florence Portet</name><name sortKey="Portet, Florence" sort="Portet, Florence" uniqKey="Portet F" first="Florence" last="Portet">Florence Portet</name><name sortKey="Portet, Florence" sort="Portet, Florence" uniqKey="Portet F" first="Florence" last="Portet">Florence Portet</name><name sortKey="Reynes, Christelle" sort="Reynes, Christelle" uniqKey="Reynes C" first="Christelle" last="Reynes">Christelle Reynes</name><name sortKey="Reynes, Christelle" sort="Reynes, Christelle" uniqKey="Reynes C" first="Christelle" last="Reynes">Christelle Reynes</name><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name><name sortKey="Sabatier, Robert" sort="Sabatier, Robert" uniqKey="Sabatier R" first="Robert" last="Sabatier">Robert Sabatier</name><name sortKey="Sabatier, Robert" sort="Sabatier, Robert" uniqKey="Sabatier R" first="Robert" last="Sabatier">Robert Sabatier</name><name sortKey="Touchon, Jacques" sort="Touchon, Jacques" uniqKey="Touchon J" first="Jacques" last="Touchon">Jacques Touchon</name><name sortKey="Touchon, Jacques" sort="Touchon, Jacques" uniqKey="Touchon J" first="Jacques" last="Touchon">Jacques Touchon</name></country><country name="États-Unis"><region name="État de New York"><name sortKey="Brickman, Adam M" sort="Brickman, Adam M" uniqKey="Brickman A" first="Adam M." last="Brickman">Adam M. Brickman</name></region><name sortKey="Muraskin, Jordan" sort="Muraskin, Jordan" uniqKey="Muraskin J" first="Jordan" last="Muraskin">Jordan Muraskin</name><name sortKey="Provenzano, Frank A" sort="Provenzano, Frank A" uniqKey="Provenzano F" first="Frank A." last="Provenzano">Frank A. Provenzano</name></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Maller, Jerome J" sort="Maller, Jerome J" uniqKey="Maller J" first="Jerome J." last="Maller">Jerome J. Maller</name></region><name sortKey="Meslin, Chantal" sort="Meslin, Chantal" uniqKey="Meslin C" first="Chantal" last="Meslin">Chantal Meslin</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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